Turkiye Klinikleri Journal of Veterinary Sciences

.: REVIEW
Hayvanlarda Böbrek Hastalıklarının Erken Teşhisinde Biyobelirteç Olarak Proteomiklerin Önemi
The Importance of Proteomics as Biomarker in Early Diagnosis of Kidney Diseases in Animals
Eda ÜLKÜa, Ramazan YILDIZb
aBurdur Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü, İç Hastalıkları ABD, Burdur, TÜRKİYE
bBurdur Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi, İç Hastalıkları ABD, Burdur, TÜRKİYE
Turkiye Klinikleri J Vet Sci. 2020;11(1):38-44
doi: 10.5336/vetsci.2019-72335
Article Language: TR
Full Text
ÖZET
 Böbrek yetmezlikleri, organ fonksiyonlarında azalma ile kendini gösteren; her yaştaki hayvanda, özellikle yaşlı hayvanlarda çok görülen önemli bir hastalıktır. Özellikle kronik böbrek yetmezliği, böbrek fonksiyonlarında geri dönüşümü olmayan azalma ile karakterizedir ve en fazla tespit edilen böbrek hastalığıdır. Böbrek hastalıklarında erken teşhis, etkili tedavi uygulamalarının yapılabilmesi açısından önem taşır. Kronik böbrek hastalığının tanısı, küçük hayvan pratiğinin önemli bir parçasıdır. Kreatinin, hastalığın erken teşhisinde yetersiz kalmaktadır. Günümüzde hastalıklar, toksik ajanlar ve ilaçların etkisiyle oluşan proteinlerin belirlenmesi ve işlevlerinin aydınlatılmasını amaçlayan birçok proteomik çalışma yapılmıştır. Proteomiklerin veteriner hekimlikte kullanımının beşeri hekimlikteki kullanımların gerisinde kalmasına rağmen son zamanlarda hayvan hastalıklarının patolojik yolaklarının araştırılmasında büyük bir ilgi alanı olmuştur. Son zamanlarda dünya çapında böbrek hastalıklarının nedenlerinin başında, glomerüler hastalıklar gelmektedir. Glomerüler hastalıkların teşhisinde kullanılabilecek idrar belirteçlerini belirlemek için insan ve hayvan modellerinde proteomik çalışmalar yapılmaktadır. Proteomik çalışmaların diğer çalışmalardan farkı, bir defada çok sayıda proteinin incelenmesine imkân sağlamasıdır. Yapılan proteomik araştırmalar sayesinde, interlökin-18, nötrofil jelatinaz ilişkili lipokalin, renal papiller antijen-1, böbrek hasar molekülü-1, simetrik dimetilarjinin, clusterin, cauxin, karaciğer tipi yağ asidi bağlayıcı protein, albümin, retinol bağlayıcı protein, sistatin C, N-asetil-β-d glukozaminidaz gibi çeşitli biyobelirteçler bulunmaktadır. Bu derlemede, hayvanlarda böbrek hastalıklarının erken teşhisinde biyobelirteç olarak proteomiklerin öneminden bahsedilmektedir.

Anahtar Kelimeler: Proteomikler; akut böbrek hasarı; kronik böbrek yetmezliği; böbrek
ABSTRACT
 Kidney failure is an important disease that occurs in animals of all ages, especially in older animals, which is manifested by a decrease in organ function. Chronic kidney failure, in particular, is characterized by irreversible reduction in kidney function and is the most common kidney disease. Early diagnosis in kidney diseases is important in terms of effective treatment applications. Diagnosis of chronic kidney disease is an important part of small animal practice. Creatinine is insufficient for early diagnosis of the disease. Today, many proteomic studies have been conducted aiming to determine the proteins formed by the effects of diseases, toxic agents and drugs and to clarify their functions. Although the use of proteomics in veterinary medicine lags behind human medical uses, it has recently been a major area of interest in the research of pathological pathways of animal diseases. Recently, glomerular diseases are the main causes of kidney diseases worldwide. In order to determine the urine markers that can be used in the diagnosis of glomerular diseases, proteomic studies are conducted in human and animal models. The difference of proteomic studies from other studies is that it allows the examination of a large number of proteins at a time. Due to proteomic research, there are various biomarkers such as interleukin-18, neutrophil gelatinase associated lipocalin, renal papillary antigen-1, kidney damage molecule-1, symmetric dimethylarginine, clusterin, cauxin, liver type fatty acid binding protein, albumin, retinol binding protein, cystatin C, N-acetyl-β-D glucosaminidase. In this review, the importance of proteomics as a biomarker in early diagnosis of kidney diseases in animals is mentioned.

Keywords: Proteomics; acute kidney injury; chronic renal failure; kidney
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Privacy Policy

We recommend you to read the terms of use below before you visit our website. In case you agree these terms, following our rules will be to your favor. Please read our Terms of Use thoroughly.

www.turkiyeklinikleri.com website belongs to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. and is designed in order to inform physicians in the field of health

www.turkiyeklinikleri.com cannot reach to user’s identity, address, service providers or other information. The users may send this information to the website through forms if they would like to. However, www.turkiyeklinikleri.com may collect your hardware and software information. The information consists of your IP address, browser type, operating system, domain name, access time, and related websites. www.turkiyeklinikleri.com cannot sell the provided user information (your name, e-mail address, home and work address, phone number) to the third parties, publish it publicly, or keep it in the website. Gathered information has a directing feature to be a source for the website’s visitor profile, reporting and promotion of the services.

www.turkiyeklinikleri.com uses the taken information:

-To enhance, improve and maintain the quality of the website

-To generate visitor’s profile and statistical data

-To determine the tendency of the visitors on using our website

-To send print publications/correspondences

-To send press releases or notifications through e-mail

-To generate a list for an event or competition

By using www.turkiyeklinikleri.com you are considered to agree that;

-Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. cannot be hold responsible for any user’s illegal and immoral behavior,

-Terms of use may change from time to time,

-It is not responsible for other websites’ contents it cannot control or the harms they may cause although it uses the connection they provided.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. may block the website to users in the following events:

-Information with wrong, incomplete, deceiving or immoral expressions is recorded to the website,

-Proclamation, advertisement, announcement, libelous expressions are used against natural person or legal identity,

-During various attacks to the website,

-Disruption of the website because of a virus.

Written, visual and audible materials of the website, including the code and the software are under protection by legal legislation.

Without the written consent of Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. the information on the website cannot be downloaded, changed, reproduced, copied, republished, posted or distributed.

All rights of the software and the design of the website belong to Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc.

Ortadoğu Advertisement Presentation Publishing Tourism Education Architecture Industry and Trade Inc. will be pleased to hear your comments about our terms of use. Please share the subjects you think may enrich our website or if there is any problem regarding our website.

info@turkiyeklinikleri.com