ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
The Role Of Secondary Chromosomal Abnormalities In The Progression Of Chronic Myeloid Leukemia Cases
Dr. Oral NEVRUZ,a Dr. Şefik GÜRAN,b Dr. Cengiz BEYAN,a Dr. Ahmet IFRAN,a
Dr. Yusuf TUNCA,c Dr. Kürşat KAPTAN,a Dr. Türker ÇETİN,a Dr. Turgay FEN,d Dr. Ali Uğur URALa
aHematoloji BD, bTıbbi Biyoloji AD, cTıbbi Genetik BD, Gülhane Askeri Tıp Akedemisi,
dDemetevler Onkoloji Hastanesi Hematoloji Bölümü, ANKARA
Objective: Chronic myeloid leukemia is a clonal bone marrow disease characterized by neoplastic overproduction of granulocytes. Nearly all chronic myeloid leukemia patients possess a single cytogenetic abnormality, t(9; 22)(q34; q11), termed the Philadelphia chromosome (Ph1). In the disease progression phase, a variety of chromosomal abnormalities have been reported with and without the presence of the Philadelphia chromosome.
Material and Methods: Here we present cytogenetic analyses of 48 patients diagnosed with chronic myeloid leukemia. The results were correlated with clinical findings.
Results: The Ph1 chromosome presented in 93.7% of all patients during the initial diagnostic phase. No other cytogenetic abnormality was evident. During the treatment phase, seven cases manifested extra chromosomal abnormalities (with six evincing the Ph1 chromosome in the initial diagnostic phase). In four cases in which extra chromosomal abnormality was noted, blastic transformation occurred. By contrast, blastic transformation developed in only two out of 42 cases with Ph1 chromosome abnormality. In one out of three Ph1-negative cases, blastic transformation was observed. This observation was short-lived due to the progression of the disease. Finally, in two patients, trisomy 8 without the Ph1 chromosome finding was seen.
Conclusion: Cytogenetic abnormalities similar to those noted in our study of chronic myeloid leukemia have been reported in the literature. These results underline the importance of the secondary chromosomal abnormalities that occur during the disease treatment phase.Keywords: Myeloid, leukemia, philadelphia chromosome, chromosome aberations, trisomyTurkiye Klinikleri J Med Sci 2005, 25:174-177
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