ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Neuronal Changes In Human Bladder With Benign Prostatic Hypertrophy
S. Tuna Karahan*, Bizden Tavil Sabuncuoğlu**, Belgin Can**
* Doç.Dr.,Ankara Üniversitesi Tıp Fakültesi Anatomi AD,
** Uz.Dr.,Ankara Üniversitesi Tıp Fakültesi Histoloji ve Embriyoloji AD, ANKARA
Normally, the bladder relaxes slowly during the filling phase. During this phase, its internal pressure does not rise too much. By the way, the gradually relaxation mechanism of bladder is not known throughly. Benign prostatic hypertrophy is seen in 50% of men over age 60, and 100% of men over age 80. Contractions, called as "uninhibited detrussor contractions" are seen in many of the benign prostatic hypertrophy patients. The reason of these contractions is thought to be the deficiency in the gradually relaxation mechanism of the bladders. In this study, bladder’s detrussor samples of 8 BPH patients and 2 normal controls were stained with NADPH-Diaphorase which is almost the same enzyme with nitric oxide synthase, the enzyme which synthesis nitric oxide. These preparations were examined hystochemically. In both control and BPH patients’ preparations, varicosities of nerves, which were stained with NADPH-Diaphorase were seen between the muscle bundles. When the NADPH-Diaphorase stained nerve fibres of BPH patients compared with the normal controls, a decrease in the neighbouring connective tissue and between the muscle bundles were seen. In the light of these findings, we think that the relaxation dysfunction of bladder, which is seen in BPH patients, may be due to the decrease in nitric oxide.
Keywords: Nitric oxide, Detrussor, NADPH-Diaphorase,
Histochemistry, Benign prostatic hypertrophy
Turkiye Klinikleri J Med Sci 1998, 18:304-308
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