ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Investigation Of The Effects Of Smoking On Lipid Peroxidation And Antioxidants In Patients With Coronary Artery Disease
Zehra SERDAR*, Melahat DİRİCAN**, Akın SERDAR***, Emre SARANDÖL*,Dilek YEŞİLBURSA****, Asuman TOKULLUGİL*****
* Uz.Dr.,Uludağ Üniversitesi Tıp Fakültesi Biyokimya AD,** Yrd.Doç.Dr.,Uludağ Üniversitesi Tıp Fakültesi Biyokimya AD,*** Doç.Dr.,Uludağ Üniversitesi Tıp Fakültesi Kardiyoloji AD,**** Yrd.Doç.Dr.,Uludağ Üniversitesi Tıp Fakültesi Kardiyoloji AD,***** Prof.Dr.,Uludağ Üniversitesi Tıp Fakültesi Biyokimya AD, BURSA
In this study, the effects of smoking on serum lipid parameters [total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C)], apolipoproteins (apo A, apo B and apo A / apo B ratio), antioxidants (vitamin E and total carotens), the lipid peroxidation product-MDA and the susceptibility to oxidation of non-HDL fraction were investigated in patients with angiographically determined coronary artery disease (CAD). 177 patients were studied. 74 patients were non-smokers (group I: 51 men, 23 women) and 103 patients were smokers (group II: 94 men, 9 women). In group II, serum lipid levels and MDA levels were significantly higher and apo A, lag-time and the level of antioxidants were significantly lower than group I. A significantly positive correlation was found between smoking and TC, TG, LDL-C and MDA, and a significant negative correlation was found between smoking and HDL-C, apo A, lag-time, vitamin E and total carotens with Spearman correlation test. There were no correlation between smoking and apo B and apo A / apo B ratio. When the patients were evaluated according to sex, smoker men with CAD had higher level of TC, TG, LDL-C, MDA and lower level of HDL-C, apo A, apo A / apo B ratio, lag-time, vitamin E and total carotens than non-smoker men with CAD. In smoker women with CAD although TC, LDL-C and MDA levels were higher and HDL-C, apo A, apo A / apo B ratio, lag-time and antioxidant levels were lower than in non-smoker CAD women, there were no significant difference.
As a result, it was shown that smoking increases both the oxidative susceptibility of non-HDL fraction and MDA which was the product of lipid peroxidation, decrease the levels of vitamin E and total carotens which were antioxidants. Also the decrease of the level of antioxidants were more significant especially in smoker men with CAD.Keywords: oronary artery disease, Smoking,
Lipid peroxidation, AntioxidantsTurkiye Klinikleri J Med Sci 1999, 19:266-274
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