ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Programmed Cell Death In Heart Failure: Review
Dr. Belgin SÜSLEYİCİ DUMAN,a Dr. Çavlan TÜRKOĞLU,b Dr. Melek ÖZTÜRKc
aTıbbi Biyoloji ve Genetik AD,bKardiyoloji AD, Kadir Has Üniversitesi Tıp Fakültesi,
cTıbbi Biyoloji AD, İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, İSTANBUL
The molecular and biochemical mechanisms of programmed cell death, also known as apoptosis, have not yet to be fully elucidated. Apoptosis is characterized by active intracellular communication, loss of cellular attachment, cell shrinkage, DNA fragmentation and phagocytosis. Recently accumulated evidence indicates that apoptosis is involved in both physiological and pathophysiological processes of heart failure. Many factors have been identified that induce cardiomyocyte apoptosis during heart failure. However, many questions remain to be answered regarding the pathophysiological triggers of apoptosis and their mechanisms. As such, due to the incipient state of research regarding the question as to whether apoptotic inhibition delays or prevents heart failure, it appears advanced molecular and pharmaco-genomic studies will be essential in identifying potential targets in prospective therapies for the prevention of apoptosis.Keywords: Heart failure, apoptosisTurkiye Klinikleri J Med Sci 2005, 25:85-92
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