ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
An Assessment Of Clinical Findings And Cervical Spinal Magnetic Resonance Imaging In Patients With Multiple Sclerosis
Dr. Bige SAYIN,a Dr. Süreyya BOYACIGİL,a Dr. Sıtkı GÜLHAN,a Dr. Enis YÜKSELa
aRadyoloji Bölümü, Ankara Numune Eğitim ve Araştırma Hastanesi, ANKARA
Objective: In this study, spinal magnetic resonance imaging (MRI) data of patients with a diagnosis of multiple sclerosis (MS) using gadolinium diethylene-3-amino penta-acetic acid were employed to search for and examine ostensible correlations between clinical findings and radiographically determined lesions and their characteristics, such as enhancement of plaques and the existence of active lesions in the corresponding spinal region.
Material and Methods: We studied 25 patients with a definite diagnosis of MS according to Poser’s diagnostic criteria. We obtained T1-weighted axial and sagittal and PDT2-weighted sagittal images of the cervical region without contrast and gadolinium enhancement. None of these patients previously had undergone cervical spinal MRI studies on clinical grounds. Demographic variables, mean disease duration, number of attacks, clinical findings, and the expanded disability status scale (EDSS) were noted. Statistical analysis was done using the chi-square test, Kruskal-Wallis variance analysis and Spearman’s correlation analysis.
Results: Seventeen of the patients (68%) had cervical spinal cord involvement. Among the various clinical course types, the median EDSS score was very close to statistically meaningful (p= 0.051). The median disease duration varied among clinical course types (p= 0.034). Kruskall-Wallis variance analysis of the course types revealed a significant difference in the number of attacks (p= 0.024). While disease duration and number of attacks revealed a statistically significant correlation (r= 0.0643, p= 0.001, respectively), duration of disease and the EDSS score had no statistical relation (r= 0.91, p= 0.666). We also noted a significant correlation between clinical course type and EDSS score (r= 0.492, p= 0.015, respectively). Plaque morphology and clinical course types were compared using chi-square analysis. No significant relation (χ2= 3.23, p= 0.358 and χ2= 5.17, p= 0.16, respectively) was found.
Conclusion: The calculated sensitivity of MRI in diagnosing MS in this study was 68%. Cervical spinal MRI evaluation of MS patients may help identify new lesions and alter treatment plans, as well as potentially avoid new neurological deficits and, therefore, lead to a better prognosis.Keywords: Multiple sclerosis, magnetic resonance imaging,gadoliniumTurkiye Klinikleri J Med Sci 2005, 25:58-64
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