ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
C-reactive Protein And The Menstrual Cycle
Dr. Simin ROTA,a Dr. Erkan ALATAŞ,b Dr. Başak YILDIRIMb
aBiyokimya AD, bKadın Hastalıkları ve Doğum AD, Pamukkale Üniversitesi Tıp Fakültesi, DENİZLİ
Objective: To investigate the changes in serum C-reactive protein (CRP) levels in women during the menstrual cycle with respect to various hormone levels.
Material and Methods: Seventeen healthy women between 20-35 years of age with regular menstrual cycles were included in the study. Blood was taken during the following 4 specific cycle phases: 1-2nd day (beginning of follicular phase), 7-9th day (follicular phase), 13-15th day (mid-cycle), 22-24th day (luteal phase). Serum follicul stimulating hormone (FSH), luteinizating hormone (LH), estradiol (E2), progesterone and high sensitive CRP levels were measured.
Results: During the menstrual cycle, there was no significant difference in CRP levels among phases. The base median level of CRP was 0.05 mg/dL (0.01-1.17 mg/dL), in the follicular phase 0.06 mg/dL (0.01-1.15 mg/dL), in mid-cycle 0.06 mg/dL (0.02-4.42 mg/dL) and in the luteal phase 0.05 mg/dL (0.01-0.13 mg/dL). However, there was a significant correlation between CRP and E2 levels during the luteal phase (r= 0.484; p= 0.049) and progesteron levels in mid-cycle (r= 0.546; p= 0.023).
Conclusion: During the menstrual cycle, CRP levels, which when high constitute a cardiovascular risk factor, displayed no significant alterations. CRP levels can be measured in all phases of the menstrual cycle.Keywords: Menstrual cycle, C-reactive proteinTurkiye Klinikleri J Med Sci 2005, 25:6-9
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