ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Homocysteine Metabolism And Association With Diseases: A Review
Dr. Miriş DİKMENa
aTıbbi Biyoloji AD, Osmangazi Üniversitesi Tıp Fakültesi, ESKİŞEHİR
Homocysteine is a sulfur-containing amino acid generated as an intermediate product in methionine metabolism. Homocysteine is metabolized by one of two pathways: re-methylation or trans-sulphuration. Although plasma homocysteine levels change between populations, it is accepted that mean total homocysteine levels range between 5-15 μmol/L. Homocysteine levels are effected by genetic defects (such as enzyme deficiencies), chronic diseases, vitamin and nutritional deficiencies, individual features (sex, age, etc.) and certain drugs. Homocysteine levels are higher in men than in women and increase with age. Elevated homocysteine levels cause hyperhomocysteinemia and homocystinuria. In addition, hyper-homocysteinemia is a risk factor for some diseases such as arterial and venous thrombosis, stroke, myocardial infarction and chronic renal failure. Increased homocysteine levels can be normalized by the administration of folic acid. Therefore, investigations of the reasons for increased plasma homocysteine and the identification of methods of maintainingKeywords: Homocysteine, hyperhomocysteinemia, homocystinuria, folic acidTurkiye Klinikleri J Med Sci 2004, 24:645-652
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