ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Effect Of Cisplatin On Bacterial Translocation In An Experimental Model With Increased Intestinal Microflora
Bahar ULUBAŞ, MD,a Gülden ERSÖZ, MD,b Banu COŞKUN, MD,c Münir TÜMKAYA, MD,a Handan ÇAMDEVİREN, MD,d
Departments of aChest Diseases, bInfection Disease, cHistopathology, dBiostatistics, Mersin University
Objective: Several reasons cause bacterial translocation and these may be increase mortality and morbidity of patients. Cisplatin is the most important antineoplastic drug in treatment of lung cancer. The aim of the study was to investigate cisplatin effect on bacterial translocation in Wistar albino rats.
Material and Methods: 15 female Wistar albino rats were studied. To rich intestinal microflora, 24 h before drug administration, all of them were given Escherichia coli suspension by oral way. Eight of the 15 rats, were given intraperitoneal Cisplatin 6 mg/kg and others were 1 mL saline solution as a control group. During study (48 h), food and drink intake were restricted to constitute starvation effect. At the end of the study, liver, spleen, ileum and arterial blood samples were obtained each sample.
Results: The mean weight of the rats was 162.66 ± 14.43 (138-182) g. Peripheral blood counts were similar each group (p> 0.307). In cisplatin administered group, bacterial growing was found on one blood culture, two mesenteric lymph node (MLN) and three spleen. Total logarithmic number of bacteriologic growing was not significant than control. On histopathology examination, necrosis in ileum was not found in groups, additionally respect to infiltration of PMNL in liver and ileum were not significant difference.
Conclusion: The presented study results implied that cisplatin administration was not increase infection risk due to bacterial translocation on experimental models.Keywords: Bacterial translocation, cisplatin, ratsTurkiye Klinikleri J Med Sci 2004, 24:633-637
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