ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Serum Total Antioxidant Status In Pulmonary Tuberculosis Patients
Dr. Tunç GÜLER,a Dr. Nermin ÇELEBİ,b Dr. Hatice SÜRER,b Dr. Fatma Meriç YILMAZ,b
Dr. Serdar GÜLER,a Dr. Tuğrul ŞİPİT,c Dr. Murat DURANAY,a Dr. Doğan YÜCELb
aII. Dahiliye Kliniği, bBiyokimya Laboratuvarı, S.B. Ankara Eğitim ve Araştırma Hastanesi,
cS.B. Atatürk Göğüs Hastalıkları ve Göğüs Cerrahisi Hastanesi, ANKARA
Objective: In the basic mechanism of the side effects of the inflammation and the drugs that are used in the treatment of tuberculosis, free radicals are thought to play an important role. The interaction between the organism and Mycobacterium tuberculosis continues until fibrosis and tissue damage occurs. In this study, we aimed to compare the total antioxidant capacity in the serum of patients having clinically-determined and microbiologic test-proven pulmonary tuberculosis and that of healthy controls in order to examine the relationship between biochemical parameters.
Material and Methods: Sixteen patients (9 male, 7 female; mean age 52 ± 21.7) and 14 apparently healthy controls (8 male, 6 female; mean age 47 ± 19.9) were included in the study. Blood samples were obtained after 12 hours fasting and total antioxidant status (TAS), uric acid, albumin, glucose, cholesterol, trygliceride and thyroid function tests were performed. TAS was determined using Randox TAS reagent, while uric acid, albumin, glucose, cholesterol and trygliceride were determined with original reagents in the Synchron LX 20 Pro analyzer. Thyroid function tests were performed in the Tosoh analyzer with the immunofluorometric method.
Results: Total antioxidant status in pulmonar tuberculosis patients was 1.13 ± 0.10 mmol/L and, in the control group, 1.23 ± 0.08 mmol/L (p= 0.016). Glucose levels were significantly higher in the patient group than in controls, and cholesterol levels were significantly lower (p= 0.002, p= 0.044). Albumin levels were significantly lower in the patient group (p< 0.001) and showed a positive correlation with TAS (p< 0.01). There was no significant difference between the 2 groups in trygliceride, uric acid levels and thyroid function tests.
Conclusion: Total activity of the antioxidant components was measured instead of determining antioxidant enzymes and molecules one-by-one. TAS was significantly diminished in pulmonary tuberculosis patients.Keywords: Pulmonary tuberculosis, antioxidantsTurkiye Klinikleri J Med Sci 2004, 24:618-623
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