ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Protective Role Of Nigella Sativa Oil On Experimental Liver Injury In Rats
Mustafa ZERİN, MD,a A. Ziya KARAKILÇIK, MD,a Yaşar NAZLIGÜL, MD,b Muharrem BİTİREN, MD,c
H. İlyas ÖZARDALI, MD,c Davut MUSAd
Departments of aPhysiology, bInternal Medicine, cPathology, Faculty of Medicine,
dDepartment of Biology, Faculty of Arts and Science, University of Harran, ŞANLIURFA
Objective: Carbon tetrachloride (CCl4) is a hepatotoxic agent used to make experimental hepatic injury. Nigella Sativa Oil (NSO) may decrease the oxidation of lipids and lipoproteins by scavenging free radicals in cellular components. Therefore, the aim of the present study was to investigate the possible protective role of NSO on activities of enzymes and on injury of the liver tissue in rats.
Material and Methods: This study was carried out on sixty Wistar albino rats divided into equally three groups. The first group was received only physiologic saline (0.9% NaCl) as a control, the second group was intraperitoneally (IP) injected carbon tetrachloride (0.15 mL/kg-body weight) and the third group was injected CCl4 (0.15 mL/kg) plus NSO (1 mL/kg-body weight). All treatments were received three times in a week for a period of the seven weeks.
Results: While plasma activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma glutamyl transferase (GGT) were statistically increased (p< 0.05 to p< 0.01) with CCl4 injection. The levels of AST, ALT and ALP were statistically decreased (p< 0.01, p< 0.05 and p< 0.05, respectively) with the treatments of NSO. Histopathologically, the liver sections of rats treated with NSO showed reduction in liver damage.
Conclusion: Based upon these results, NSO may play a protective role in the diminution of hepatic cellular injury produced by CCl4.Keywords: Liver, injury, enzymes, carbon tetrachloride, nigella sativa, ratsTurkiye Klinikleri J Med Sci 2004, 24:598-602
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