ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
|
|
|
|
ORIGINAL RESEARCH ARTICLES |
Urinary Hypoxanthine And Xanthine Levels In Type 2 Diabetes Mellitus
Belgin ŞENOL, MD,a Nevbahar TURGAN, MD,b Bilgin ÖZMEN, MD,c Ceyda KABAROĞLU, MD,b
Sara HABİF, MD,b Işıl MUTAF, MD,b Dilek ÖZMEN, MD,b Oya BAYINDIR, MD,b
Department of aBiochemistry, bClinical Biochemistry, Ege University Faculty of Medicine, İZMİR
cDepartment of Endocrinology, Celal Bayar University Faculty of Medicine, MANİSA
Objective: Complications of the vascular tree are the leading causes of morbidity and mortality in patients with diabetes mellitus. Besides the well-recognized microvascular complications of diabetes, there is as well a growing epidemic of macrovascular complications, particularly in the type 2 diabetic population. Hyperglycemia-induced pseudo-ischemia and oxidative stress are suggested to play a role in the patho-mechanism of vascular damage. The impaired ATP metabolism observed in ischemic conditions results in increased production of the purine degradation products, hypoxanthine and xanthine. The aim of this study was to investigate the relevance of hypoxanthine and xanthine levels to microvascular complications observed in type 2 diabetic patients.
Material and Methods: The study included 40 patients with type 2 diabetes mellitus (29 patients were microalbuminuric and 11 were normoalbuminuric) and 30 sex-matched controls. Serum creatinine, urea, uric acid and urine creatinine, uric acid and microalbumin levels were determined. Urinary excretion of hypoxanthine and xanthine was assessed by HPLC with UV detection.
Results: Urinary xanthine and hypoxanthine excretions were significantly increased in the patients when compared with healthy controls (p< 0.05). However, no significant difference was observed between the normoalbuminurics and microalbuminurics.
Conclusion: As a consequence of hyperglycemia-induced pseudo-hypoxia, in type 2 diabetes mellitus, ATP metabolism deteriorates and an increase in purine metabolism is observed. Urinary xanthine and hypoxanthine levels are increased in diabetic patients.Keywords: Hypoxanthine, xanthine, diabetes mellitusTurkiye Klinikleri J Med Sci 2004, 24:579-584
|
|
|
|
|
