ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Apoptosis: Programmed Cell Death
Ayşe Gaye TOMATIR*
*Pamukkale Üniversitesi Denizli Sağlık Hizmetleri Meslek Yüksekokulu, DENİZLİ
Philosophers have spent great effort for many centuries in searching the meaning of life, although cell biologists have become more familiar with the meaning of death. Until early 1970s, necrosis was the only explanation for cell death with the assumption of a nonphysiological and detrimental event. But the death of cells in human tissues and other multicellular organisms is always neither abnormal nor detrimental. Bioenergetics of cell death due to apoptosis is a more subtle event without massive cellular injury and inflammation. The role of programmed cell death or apoptosis in the development and maintenance of homeostasis within all multicellular organisms was firstly described by Kerr et al in 1972. Apoptotic cell death consists of three major components: the Bcl-2 family proteins, the caspases, and the apoptotic protease activating factor-1. Biochemical activation of these key components is responsible for the morphological changes observed in apoptosis including mitochondrial damage, nuclear membrane break down, DNA fragmentation, chromatin condensation, and the formation of apoptotic bodies. Dysregulation of apoptosis is also associated with the pathogenesis of a wide array of diseases: cancer, neurodegenaration, autoimmunity, heart disease, and other disorders. Apoptotic genes and gene products involved of apoptosis are potential targets for the diagnostic and therapeutic purposes, offering novel applications in the treatment of a wide array of maladies. In this paper, the nature of apoptosis including the necrosis, its involvement in different diseases, morphological characteristics and genetic regulation is reviewed.Keywords: Apoptosis, Necrosis, Caspases, Disease, therapyTurkiye Klinikleri J Med Sci 2003, 23:499-508
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