ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
|
|
|
|
ORIGINAL RESEARCH ARTICLES |
Comparison Of Insulin Lispro And Regular Human Insulin
Hanife EKER*, Zeliha HEKİMSOY**, Bülent SÖZMEN*, Leyla ARSLAN***
* Uz.Dr., Atatürk Eğitim ve Araştırma Hastanesi, 3. İç Hastalıkları Kliniği, İZMİR
** Uz.Dr., Celal Bayar Üniversitesi İç Hastalıkları AD, Endokrinoloji BD, MANİSA
*** Doç.Dr., Atatürk Eğitim ve Araştırma Hastanesi, 3. İç Hastalıkları Kliniği, İZMİR
Objectives: We aimed to compare the effects of insulin Lispro and regular human insulin on glisemic control and hypoglycaemia frequency on diabetic patients receiving intensive insulin treatment.
Material and Methods: A study on 40 diabetic patients for 3 months has been performed. Patients were divided into 2 groups and one group was given insulin Lispro before meals and the other was given regular human insulin. Both groups were given NPH insulin at night. In all of the patients basal HbA1c and then HbA1c at 3rd month of the treatment were performed. Patients measured and recorded blood glucose levels at home using a home blood glucosemeter before and 2 hours after breakfast, lunch and dinner, and at night at 23. The blood glucose profiles at fasting and postprandial measurements, hypoglycaemia frequency and HbA1c levels were compared.
Results: There were no statistically significant differences between groups considering age, sex, body mass index, blood glucose levels at fasting and postprandial, HbA1c, diabetes type, duration and complications. The preprandial and postprandial blood glucose levels at the first month of the treatment in patients receiving insulin Lispro and regular insulin were 157.75±25.76 mg/dl and 167.83±33.70 mg/dl, (p=0.3); 157.63±28.7 mg/dl and 187.65±38.82 mg/dl, (p=0.01) respectively. The preprandial and postprandial blood glucose levels at the second month of the treatment in patients receiving insulin Lispro and regular insulin were 103.81±5.74 mg/dl and 111.45±8.11 mg/dl, (p=0.004); 111.98±11.9 mg/dl and 116±9.18 mg/dl, (p=0.23) respectively. The preprandial and postprandial blood glucose levels at the third month of the treatment in patients receiving insulin Lispro and regular insulin were 100.63±8.08 mg/dl and 106.5±5.88 mg/dl, (p=0.002); 108.18±6.86 mg/dl and 116.08±9.84 mg/dl, (p=0.01) respectively. There were no statistically significant differences between groups considering hypoglycaemia frequency. The basal HbA1c was in Lispro group %10.2±1.5, in regular insulin group %10.7±1.4. Control HbA1c in Lispro group was %6.5±0.5, in regular insulin group %6.7±0.5.
Conclusion: This study is confirming that insulin Lispro provides a good glisemic control in intensive treatment of diabetes without increasing the frequency of hypoglycaemia.Keywords: Diabetes Mellitus, InsulinTurkiye Klinikleri J Med Sci 2003, 23:471-475
|
|
|
|
|
