ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Tubular Function In Pregnant Women With
Tevfik NOYAN, MD,a M.Ramazan ŞEKEROĞLU, MD, a Haluk DÜLGER, MD, a Mansur KAMACI, MDb
aDepartment of Biochemistry, bDepartment of Gynaecology and Obstetrics, Yüzüncü Yıl University School of Medicine, VAN
Objective: Preeclampsia (PE) is a frequently occurred complication of pregnancy. PE often has renal involvement characterised by proteinuria, and decreased glomerular filtration. The aim of this study was to investigate the changes of urinary and fractional excretion (FE) of beta-2 microglobulin (β2M) as indicator of tubular function in both preeclamptic and normal, healthy pregnant women as compared to healthy, non-pregnant women.
Material and Methods: Twenty third-trimester pregnant women with PE (group 1), 20 third-trimester healthy pregnant women (group 2), and 20 healthy, non-pregnant women (group 3) were included in the present study. The serum and urinary levels of beta-2 microglobulin were measured and fractional excretion (FE) of β2M was determined in each group. The urinary value obtained for β2M was then expressed per gram of creatinine (β2M/Cr).
Results: The urinary β2M/Cr ratio was statistically higher in both group 1 and group 2 when compared to group 3 (p<0.001), but there was no significant difference between group 1 and group 2 (p>0.05). The serum β2M levels were significantly higher in group 1 when compared with those in group 2 and group 3 (p<0.01), and there was no significant difference between group 2 and group 3 (p>0.05). FE of β2M increased significantly in group 1 and group 2 compared with that in group 3 (p<0.05), and there were no significant differences between group 1 and group 2 (p>0.05).
Conclusion: The results of our study indicate that urinary and fractional excretion of β2M significantly increased in preeclampsia and in normotensive pregnancy as compared to healthy, non-pregnant women and these increases might indicate tubular dysfunction.Keywords: Preeclampsia, β2M, tubular dysfunctionT Klin J Med Sci 2004, 24:1-5
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