ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Protective Effect Of Caffeic Acid Phenethyl Ester On Myocardial Ischemia/reperfusion-induced Histological Alterations
Dr.Nigar VARDI,a Dr.Hakan PARLAKPINAR, b Dr.Mukaddes EŞREFOĞLU, a Dr.Muharrem UÇARc
aHistoloji-Embriyoloji AD, bFarmakoloji AD, cAnesteziyoloji ve Reanimasyon AD, İnönü Üniversitesi Tıp Fakültesi, ELAZIĞ
Objective: To aim of this study was to investigate the purported protective effect of caffeic acid phenethyl ester (CAPE) against myocardial ischemia/reperfusion.
Material and metods : Twenty-four Wistar rats were randomly divided into three groups: Sham operation, ischemia/reperfusion (I/R) and I/R + CAPE. To produce I/R, the left main coronary artery was occluded for 30 minute, followed by 120 minute reperfusion. The tiobarbituric acid method was used to determine tissue malondialdehyde( MDA) levels as an indicator of lipid peroxidation in the heart. Histological changes were evaluated with ligth microscopy.
Results: I/R was accompained by a significant increase tissue MDA whereas CAPE administration significantly reduced this substrate. I/R induced myocardial damage, which manifested by histopathological evidence of intracelluler vacuolization, reduction in cytoplasmic glycogen granules, neutrophil adhesion to endothelium, mast cell degranulation and coagulation necrosis. These changes induced by I/R were ameliorated with CAPE.
Conclusion: This study shows that CAPE can be regarded as a protective agent action against I/R-induced myocardial damage.Keywords: Ischemia, reperfusion, myocardium, microscopyTurkiye Klinikleri J Med Sci 2004, 24:469-475
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