ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
The Role Of Radiotherapy In Pancreatic Cancer: Retrospective Evaluation
Dr.Diclehan ÜNSAL,a Dr.Müge AKMANSU, a Dr.Hüseyin BORA, a Dr.Aytuğ ÜNER, bDr.Petek TATER, a Dr.Yücel PAKa
aRadyasyon Onkolojisi AD, aTıbbi Onkoloji BD, Gazi Üniversitesi Tıp Fakültesi, ANKARA
Objective: To determine the properties and the efficiency of radiotherapy in our patients with pancreatic cancer in a retrospective manner.
Material and Methods: Between 1998 and 2003, 34 patients with pancreatic carcinoma were treated with radiotherapy. The mean age was 58.0 (36-75). The types of radiotherapy were postoperative adjuvant irradiation after Whipple operation in 11 patients and irradiation due to inoperability in 24 patients. 1 patient was stage 1, 1 patient was stage 2, 10 were stage 3, 17 were stage 4A and 6 patients were 4B. Histological grades was unknown in 9 patients, grade 1 in 5 patients, grade 2 in 9 and grade 3/4 in 11 patients. The tumor location was pancreas head in 30 patients, head and corpus in 3 patients and corpus alone in 1 patient. For 16 of the 23 patients irradiated because of inoperability and all of the 11 patients irradiated postoperative adjuvantly, FU or gemcitabine-based chemotherapy was administered concomitant to radiotherapy (4500-5220 cGy).
Results: The overall survival was 23.27±4.02 months in patients administered postoperative adjuvant treatment, 14.01±2.94 months treated with radiotherapy and chemotherapy and 8.820.82 months treated with radiotherapy alone (p=0.454). In univariate analysis, treatment administered, CA 19.9 level and stage were found to be statistically significant. In multivariate analysis, the stage was found to have a trend to significance.
Conclusion: The primary treatment modality is surgery in pancreatic cancers. Few of the small number of patients treated with surgery plus adjuvant treatment have a chance of long-term survival. Although the standard treatment in locally advanced pancreatic cancers is chemoradiotherapy, complete response rates are low and overall survival ratios are poor.Keywords: Pancreatic cancer, radiotherapy, prognosisTurkiye Klinikleri J Med Sci 2004, 24:483-491
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