ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Cd45, Cd45ra, Cd53, Cd146, Cd5, Cd55, Cd52 And Fibrinogen Antigen Expression In Human Palatine And Nasopharyngeal Tonsils
Dr. Lale KARAKOÇ SÖKMENSÜER, a Dr. Sevda MÜFTÜOĞLUa
aHistoloji ve Embriyoloji AD, Hacettepe Üniversitesi Tıp Fakültesi, ANKARA
Objective: We present an immuno-phenotypic analysis and comparision of the epithelial, stromal and lymphoid tissue components of the human palatine and nasopharyngeal tonsils.
Material and Methods: Tissue samples of 20 patients (ages 3-14) undergoing tonsillectomy and adenoidectomy due to recurrent tonsillitis and adenoid hypertrophy in Otorhinolaryngology Department, Hacettepe University Medical Faculty Hospital, were obtained as partial surgical specimens apart from routine patholojic examination. Tissues were stained for CD45, CD45RA, CD53, CD146, CD5, CD55, CD52, and fibrinogen monoclonal antibodies by using the indirect immunoperoxidase technique.
Results: We observed no prominent immuno-phenotypic differences in epithelial and stromal cells of the palatine and nasopharyngeal tonsils. However, a weaker molecular expression of antigens was observed in nasopharyngeal lymphoid cells. Also, lymphocyte infiltration was more prominent in palatine tonsils than in nasopharyngeal tonsils. Additionally, specific and previously unreported immune reactivity of CD53, CD146 and CD52 and fibronogen was detected and discuised.
Conclusion: Although the immunoreactivity observed in both tonsils was similar in the cellular aspect, we conclude that differences in the reactive intensity between nasopharyngeal and palatine tonsils were evidentKeywords: Palatine tonsil, nasopharyngeal tonsil,
immunohistochemistry, antigenTurkiye Klinikleri J Med Sci 2004, 24:450-460
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