ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Levels Of Serum Acute-phase Proteins In Patients With Asthma
Mukadder ÇALIKOĞLU, MD,a Ali ÜNLÜ, MD, b Lülüfer TAMER, MD, b
İlker ÇALIKOĞLU, MD, c Gürbüz POLAT, MD, b
Department of Chest Disease, bBiochemistry, Mersin University, Faculty of Medicine
cClinic of Biochemistry State Hospital of Silifke, MERSİN
Objective: Bronchial asthma is an inflammatory disease which high numbers of cytokines play an important role in the pathogenesis of the disease. Production of the acute-phase proteins (APP) is under the control of several cytokines. The aim of this study was to investigate serum APP levels in patients with stable asthma.
Material and Methods: Forty asthma patients and thirty apparently healthy controls attended to this study. All the patients and controls were undertaken to history, physical examination, chest radiogram, blood count, routine biochemical investigation, skin prick test and pulmonary function tests. Asthma was diagnosed according to the American Thoracic Society Statement. Venous blood samples were obtained and used for C-reactive protein (CRP), ceruloplasmin, transferrin, haptoglobin and 1-acid glycoprotein (AAGP) detection. APP levels were determined by immunoturbidometrical methods.
Results: CRP levels were higher in the patients group than the controls (p= 0.007). While AAGP (p= 0.006) and ceruloplasmin (p= 0.000) levels were higher, transferrin (p= 0.000) and haptoglobin (p= 0.009) levels were lower in the patients than the controls. APP levels were not affected from smoking, FEV1 levels, steroid use, allergic rhinitis, atopy and eosinophili in the patient group.
Conclusion: All of the acute-phase protein levels, which were measured in this study, were observed significantly different in the asthmatic patients in comparison to the controls. In order to determine whether these APP are useful for the demonstration and follow-up of the inflammation in asthma patients, patients who have different stages of the disease and other certain inflammation markers should be performed in future studies.Keywords: Asthma, acute-phase proteinsTurkiye Klinikleri J Med Sci 2004, 24:440-444
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