ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Serum Homocysteine, Lipoprotein (a), Tumor Necrosis Factor-alpha, Total Cholesterol And Triglyceride Levels In Hemodialysis Patients
Neslihan BUKAN, MD, (a) Banu SANCAK, MD, (a) Hatice PAŞAOĞLU, MD, (a) Şehri ELBEG, MD, (a)
Adem ÜNAL, MD, (a) Yasemin ERTEN, MD, (b)
Objective: Hyper-homocysteinemia and lipoprotein (a) (Lp(a)) are accepted independent risk factors for atherosclerotic process. Lipid abnormalities are important variables in patients with end-stage renal disease (ESRD) in the development of vascular atherosclerotic lesions. In most hemodialysis (HD) patients, serum levels of Lp(a) and homocysteine are markedly elevated and contribute to premature atherosclerosis in these patients. Cytokines such as tumor necrosis factor-alpha (TNF-α) can alter lipid metabolism and produce hyperlipidemia. In this study we purposed to evaluate the changes of these parameters with the application of hemodialysis.
Material and Methods: In this study thirty patients undergoing dialysis were selected. Serum levels of Lp(a), TNF-α, total cholesterol and triglyceride levels were measured before and after hemodialysis.
Results: Serum Lp(a) and TNF-α were significantly increased after hemodialysis. However, there was no difference statistically in homocysteine, total cholesterol and triglyceride levels between the pre- and post-HD period.
Conclusion: These results indicate that Lp(a) and TNF-α levels were markedly elevated in ESRD patients after HD and contributed to possible atherosclerotic process. The acute rise of TNF-α, however, had no effect on other serum lipid and homocysteine levels.Keywords: Hemodialysis, homocysteine, lipoprotein (a), tumor necrosis factor-alpha, lipidTurkiye Klinikleri J Med Sci 2004, 24 :435-439
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