ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Angiogenesis And The Role Of Anti-angiogenic Therapy In Cancer Treatment
Dr.Şefik GÜRAN,a Dr.Turgay FEN,b Dr.Yusuf TUNCAc
aTıbbi Biyoloji AD, cTıbbi Genetik BD, GATAbHematoloji Bölümü, Demetevler Onkoloji Hastanesi, ANKARA
Angiogenesis, or the formation of new blood vessels, is considered to be the sole mechanism of blood vessel formation in postnatal life. Angiogenesis is essential for normal reproduction, development, and repair. In adults, stimuli such as hypoxia “turns on” the angiogenic “switch”. Tumor growth depends on angiogenesis and tumors might activate resting endothelial cells to proliferate by secreting a “diffusable” chemical signal. Without angiogenesis, primary tumors or metastases cannot develop into clinically significant disease. The combined necessity for tumors to create new blood vessels to grow and the restriction of normal angiogenesis in healthy adults to only a few short-lasting situations therefore provides a very selective target for anti-angiogenic cancer therapies. Drugs directed at the factors activated in angiogenesis [e.g. epidermal growth factor receptors, vascular endothelial growth factors, integrins, MMPs cyclooxygenase-2 (COX-2)] have begun to find a place in cancer treatment. Transfer of blocking agents of these factors to the tumor area in appropriate conditions has provided hope for the development of future cancer therapy schemes.Keywords: Angiogenesis, antiangiogenic treatment,
vascular endothelial growth factor,
epidermal growth factor receptorsTurkiye Klinikleri Tıp Bilimleri 2004, 24:380-382
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