ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
The Effect Of N-acetylcystein On The Increase Of Nitric Oxide Meta-bolites Observed In Oleic Acid-induced Acute Lung Injury
Dr.Oğuz KÖKSEL,a Dr.Lülüfer TAMER,b Dr.Ali ÖZDÜLGER,a
Dr.Menderes ERÇİL,a Dr.Bahadır ERCAN,b Dr.Arzu KANIKc
aGöğüs Cerrahisi AD, bBiyokimya AD, cBiyoistatistik AD, Mersin Üniversitesi Tıp Fakültesi, MERSİN
Objective: To explore the changes in serum nitric oxide metabolite levels as a consequence of oleic acid (OA) -induced acute lung injury and to describe the effects of N- acetylcysteine (NAC) treatment on OA metabolite levels in an experimental rat model.
Material and Methods: Five groups of rats, each containing 7 animals, were used in this study. OA was dissolved in ethanol and diluted with saline. Group 1 (sham) was given saline (NaCl 0.9%) and ethanol; group 2 (NAC) was administered NAC, saline and ethanol; group 3 (OA) received OA, saline and ethanol; group 4 (Pre-OA-NAC) received NAC 15 minutes before oleic acid infusion; group 5 (Post-OA-NAC), received NAC two hours after OA infusion. In all of the groups blood samples were taken 4 hours after OA infusion following mid-line sternotomy with cardiac puncture. Serum nitrite and nitrate levels were measured.
Results: Serum total nitrite and nitrate levels in the OA-Group were found to be increased significantly when compared with the shams (p<0.001), whereas NAC administration caused a significant decrease in serum total nitrite/nitrate levels in both pre-OA-NAC (p<0.001) and post-OA-NAC (p<0.001) groups.
Conclusion: It was shown that serum nitric oxide metabolite levels increased as an injury marker in this OA-induced acute lung injury model. NAC was effective in decreasing nitric oxide metabolite levels.Keywords: Acute lung injury, oleic acid, N-Acetylcysteine, nitric oxide metabolitesTurkiye Klinikleri J Med Sci 2004, 14:323-327
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