ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Serum Malondialdehyde Levels And Susceptibility To Oxidation In Patients Undergoing Hemodialysis And Peritoneal Dialysis
Dr.Elmas ÖĞÜŞ, a Dr.Fatma Meriç YILMAZ, a Dr.Hınç YILMAZ, b Dr.Murat DURANAY,b Dr.Doğan YÜCELa
aBiyokimya Laboratuvarı, bDiyaliz Bölümü, S.B Ankara Eğitim ve Araştırma Hastanesi, ANKARA
Objective: In this study, serum malondialdehyde (MDA) levels before and after oxidation were determined in 21 hemodialysis patients in the pre- and postdialysis period, in 21 peritoneal dialysis patients, and in 20 healthy controls.
Material and Methods: MDA was determined with the Hunter method. Cupric sulfate and hydrogen peroxide was used for the oxidation of sera.
Results: Serum MDA levels were higher in pre- and post-hemodialysis as well as in peritoneal dialysis patients when compared to those of controls. There was no significant difference between the predialysis, postdialysis and peritoneal dialysis groups (predialysis: 5.9 ± 1.4 μmol/L ; postdialysis: 7.3 ± 3.2 μmol/L , peritoneal dialysis: 6.5 ± 2.2 μmol/L; and control: 3.8 ± 0.6 μmol/L; p<0.01, p<0.0001, p<0.001, respectively). After oxidation of the sera, MDA was significantly higher in the postdialysis group than in the predialysis and peritoneal dialysis patients (p=0.002, p=0.0002, respectively). There was no significant difference between predialysis and peritoneal dialysis groups. However, MDA levels were higher in predialysis, postdialysis and peritoneal dialysis groups than controls (predialysis: 8.9 ± 3.9 μmol/L; postdialysis: 14.3 ± 7.5 μmol/L; peritoneal dialysis: 7.6 ± 3.9 μmol/L and control: 4.0 ± 0.4 μmol/L; p<0.01, p<0.0001, p<0.05, respectively).
Conclusion: Oxidative stress was higher in both hemodialysis and peritoneal dialysis groups than controls, but there was no significant difference between hemodialysis and peritoneal dialysis groups. However, susceptibility to oxidation was increased significantly in postdialysis group when compared with predialysis and peritoneal dialysis groups.Keywords: Hemodialysis, peritoneal dialysis, oxidative stress, susceptibility to oxidation, malondialdehydeTurkiye Klinikleri J Med Sci 2004, 24:316-322
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