ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Plasma Malondialdehyde Levels In Migraine With And Without Aura
Dr.Gülsen YILMAZ,a Dr.Hatice SÜRER,a Dr.Serap ÜÇLER,b Dr.Levent İNAN,b Dr.Doğan YÜCELa
aBiyokimya Laboratuvarı, bNöroloji Kliniği, S.B. Ankara Eğitim ve Araştırma Hastanesi, ANKARA
Objective: In this study, in order to investigate the effects of oxidative stress in migraine patients, we measured plasma malondialdehyde (MDA), thiol (SH), uric acid, albumin and bilirubin levels in such patients and compared them with healthy controls.
Material and Methods: A total of 36 patients with migraine (22 without aura, 14 with) in headache-free periods and 16 patients with migraine (11 without aura, 5 with) in attack periods participated in our study. The control group consisted of 20 healthy subjects.
Results: Plasma MDA levels were 8.0 ± 4 μmol/L during headache-free periods, 6.9 ± 3.0 μmol/L during attacks and 5.2 ± 1.9 μmol/L in controls. Plasma MDA levels were significantly higher in patients during headache-free periods than in controls. (p=0.001) There was no significant difference between controls and patients during attacks (p>0.05). When the patients were divided into subgroups of migraine with and migraine without aura, plasma MDA levels were significantly higher than in controls in both subgroups during headache-free periods (p=0.033 and p=0.000, respectively). Although no significant difference was found in patients with aura during attacks, a significant difference was found in patients without aura during attacks (p=0.144 and p=0.011, respectively). Plasma antioxidants such as thiol groups (SH), uric acid, albumin and bilirubin showed no significant difference between patients and controls.
Conclusion: When compared with controls, higher MDA levels were found in migraine patients with and without aura during headache-free periods and in patients without aura during attacks. It has been postulated that the synthesis of free radicals may trigger migraine attacks by increasing oxidative stress.Keywords: Migraine, oxidative stress, malondialdehyde, thiol groups, antioxidantsTurkiye Klinikleri J Med Sci 2004, 24:309-315
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