ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
|
|
|
|
ORIGINAL RESEARCH ARTICLES |
Reduced Glutathione And Antioxidant Enzyme Activities In Erythrocytes Of Patients With Iron-deficiency Anemia
Dr.Keriman YILMAZ,a Dr.Ahmet KAHRAMAN,a Dr.Sevgi BODUR,a Dr.Sibel KOÇAR,a Dr.Tülay KÖKENa
aBiyokimya AD, Afyon Kocatepe Üniversitesi Tıp Fakültesi, AFYON
Objective: The present study was performed to evaluate erythrocyte antioxidant enzymes in patients with iron-deficiency anemia (IDA). Alterations in plasma end-products of oxidative damage were investigated as well.
Material and Methods: Erythrocyte superoxide dismutase (SOD), catalase (CAT) activities and reduced glutathione (GSH) levels were evaluated in 20 patients with IDA and compared to those in a control group. In addition, we measured the concentrations of plasma malonyldialdehyde (MDA), protein carbonyl content and total sulphydryl (SH) groups.
Results: Erythrocytes GSH levels in IDA patients were significantly lower than those in the controls (p<0.01). Erythrocyte SOD and CAT activities were also significantly higher in IDA patients (both p<0.001). There were no significant differences in MDA and protein carbonyl content levels between the two groups. However, total SH group levels were significantly lower in IDA patients (p<0.01).
Conclusion: Decreased erythrocyte GSH levels, an essential factor for membrane mechanical integrity in IDA, may cause membrane instability and contribute to decreased erythrocyte half-life.Keywords: Iron-deficiency anemia, superoxide dismutase, catalase, reduced glutathioneTurkiye Klinikleri J Med Sci 2004, 24:305-308
|
|
|
|
|
