ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Do Thyroid Hormones And Famotidine Preventgastric Erosion If Used Before Stress?
Haldun GÜNDOĞDU*, Seher DEMİRER**, Ayhan KOYUNCU***, Semih AYDINTUĞ****
*Dr.Türkiye Yüksek İhtisas Hastanesi Gastroenteroloji Cerrahisi Kliniği Başasistanı,
**Uz.Dr.AÜTF Genel Cerrahi ABD,
***Dr.AÜTF Genel Cerrahi ABD Araştırma Görevlisi,
****Prof.Dr.AÜTF Genel Cerrahi ABD, ANKARA
Upper gastrointestinal bleeding is a serious complication frequently detected in various patient groups under stress. Several studies showed that thyroid functions may have an affect on the development of stress ulcer.
The aim of this study is to investigate whether thyroid hormones and famotidine given before stress can be effective in prevention of gastric mucosal lesions and to compare this with the effect of famotidine given during stress.
In this study, 50 rats were included. The rats were divided into 5 groups consisting of 10 animals in each. Each group underwent starvation for 24 hours without water restriction followed by an immobilization period of 6 hours. In group I, T3 was given before stress whereas in group II T4 and in group III famotidine were given before stress. In group IV, famotidine was given at the beginning of the stress and continued during the stress period. In group V, no medication was given. All the rats underwent laparotomy and the gastric mucosal lesions were examined. There was no significant difference between the groups which had received T3, T4 and famotidin for 2 days before laparotomy. No statistically significant difference was found between the group I,II,III and the group that was given famotidine during the stress period (p>0,05). The comparison of gastric mucosal lesions in these four groups with the control group, revealed a statistically significant difference (p<0,001).
As a result, administration of thyroid hormones or famotidine which is widely used shortly before stress was found to be as effective as administration of famotidin during stress.
Keywords: Stress ulcer, thyroid hormones, famotidin
Turkiye Klinikleri J Med Sci 1997, 17:137-140
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