ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Nitric Oxide: Physiology And Clinical Importance
Atilla GÜRAY*, Nedim SAMANCI**, Fahri OVALI**, Türkân DAĞOĞLU***
*Arş.Gör.Dr.İ.Ü.İstanbul Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları ABD,
**Uzm.Dr.İ.Ü.İstanbul Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları ABD, Yenidoğan Ünitesi,
***Prof.Dr.İ.Ü.İstanbul Tıp Fakültesi Kadın Hastalıkları ve Doğum ABD, Yenidoğan Ünitesi, İSTANBUL
Nitric Oxide is a multifunctional biological mediator with diverse roles in the cardiovascular, neurological, immunological and many other systems. Besides its vasodilator effects on vascular smooth muscle cells, it acts as a signalling molecule in endothelial and nerve cells and as a killer molecule by activated immune cells. Agonists and antagonists of nitric oxide have been used in conditions such as importence, septic shock, urinary incontinence, type 1 Diabetes Mellitus. However, inhaled nitric oxide as a specific pulmonary vasodilator has been investigated in detail and it is potentially usefil in the treatment of pulmonary hypertension and ventilation-perfusion mismatch.
Nitric oxide is used succesfully as a selective pulmonary vasodilator in neonates with persistent pulmonary hypertension, children with congenital heart disease, and in adults with pulmonary hypertension or with adult respiratory distress syndrome.
Keywords: Nitric oxide, Pulmonary hypertension
Turkiye Klinikleri J Med Sci 1997, 17:115-119
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