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Plasma Atrial Natriuretic Peptide, Vasopressin, Aldosterone Andplasma Renin Activity In Rabbits Exposed To Common Bile Duct Ligation
Mahmut BAŞOĞLU*, Mehmet İlhat YILDIRGAN*, Ahmet KIZILTUNÇ**,
Zühal UMUDUM***, İbrahim KAVAK****, Durkaya ÖREN*****
*Yrd.Doç.Dr.Atatürk Üniversitesi Tıp Fakültesi Genel Cerrahi ABD,
**Dr.Atatürk Üniversitesi Tıp Fakültesi Biyokimya ABD, Öğretim Üyesi,
***Yrd.Doç.Dr.Atatürk Üniversitesi Tıp Fakültesi Biyokimya ABD,
**** Asis.Dr.Atatürk Üniversitesi Tıp Fakültesi Genel Cerrahi ABD,
*****Prof.Dr.Atatürk Üniversitesi Tıp Fakültesi Genel Cerrahi ABD, ERZURUM
In experimental studies, extracellular fluid compartment was shown to be reduced after common bile duct ligation. For determining the importance and relations of parameters that may contribute to this reduction, plasma Na+, ANP, PRA, aldosteron and ADH values were measured in rabbits at the 24th and 72nd hours of common bile duct ligation. The animals were divided into two groups: group 1 (n=15) Sham control group, group 2 (n=15) jaundice group. Plasma ANP levels of group 2 animals were higher than those of group 1 animals both at the 24th and 72nd hours (p<0.001 and p<0.01, respectively). Additionally, plasma aldosteron, total bilirubin and Na+ levels were found to be significantly higher in group 2 than in group (p<0.001 for all). While PRA at the 72nd hour of common bile duct ligation was higher in group 2 (p<0.001), there was not any significant difference in values obtained at the 24th hour. Group 2 rabbits had increased plasma ADH values both at the 24th and 72nd hours when compared to sham control group.
In conclusion, it was found that plasma ANP levels increased in rabbits with obstructive jaundice, probably in response to increased plasma ADH, aldosteron, PRA (only at the 72nd hours) and Na+ that might be responsible for reduction in extracellular compartment.
Keywords: Obstructive jaundice, ANP
Turkiye Klinikleri J Med Sci 1997, 17:39-42
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