ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Combined Oral Contraceptives: Risks And Benefits
Aylin GÜRBAY*, Belma GİRAY*, Filiz HINCAL**
*Uzm.Ecz.Hacettepe Üniversitesi Eczacılık Fakültesi, Farmasötik Toksikoloji ABD,
**Prof.Dr.Hacettepe İlaç ve Zehir Bilgi Merkezi, ANKARA
Combined oral contraceptives are a mixture of two steroid hormones, a synthetic estrogen and a progestogen. Their primary mechanism of action is to prevent ovulation by suppressing pituitary gonadotropin secretion. They are the most effective means for contraception excluding sterilization and because of effectiveness, reversibility and convenience they are used as an extremely popular method of family planning. It is estimated that oral contraceptives are being used by over 60 million women around the world, therefore their safety for short-term and long-term use is a public health issue of great concern. A large number of epidemiological studies which have become more rigorous, and increased in size and improved in methodology in years have provided an encouraging assessment of oral contraceptives. The bulk of recent data suggest that the newer formulations no longer appear to be associated with an increased risk of myocardial infarction or stroke; they protect against the development of ovarian and endometrial cancers; cancer risk, however seems to be associated with an increased risk both in the early and late fertile years; and the relationship between their use and cervical cancer risk remains to be controversial due to methodological problems. It is generally agreed that when used by healthy women, the noncontraceptive benefits of oral contraceptives outweigh the risks involved.
Keywords: Oral contraceptives, Risk of cancer,Cardiovascular effects
Turkiye Klinikleri J Med Sci 1997, 17:1-14
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