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Altered Plasma Sex Hormone Levels In Adultmale Rats Following Serious Acute Blood Loss
Serdar YARDIMCI*, M.Cem KOÇKAR**, Tuncay DELİBAŞI**, Hakkı TAŞTAN***, Sema YAVUZER*
*Doç.Dr.Ankara Üniversitesi Tıp Fakültesi, Fizyoloji ABD,**Dr.Ankara Numune Hastanesi, Endokrinoloji ve Metabolizma Hastalıkları Kliniği,***Dr.Ankara Üniversitesi Fen Fakültesi, Biyoloji ABD,****Prof.Dr.Ankara Üniversitesi Tıp Fakültesi, Fizyoloji ABD, ANKARA
In the present investigation, the changes in levels of plasma testosterone, FSH, and LH related with acute serious blood loss were examined. For this purpose, 2 cc blood/100 g body weight (approximately 30% of total blood volume) was taken from adult male rats by intracardiac puncture under light ether anesthesia. The first measurements were used as control values. Ten days later, blood samples were taken again and measurements of all parameters were repeated. At the 10th day after blood taken mean plasma testosterone level was found to be decreased significantly. Mean plasma FSH and LH levels were significantly higher than the control values. It has not been obtained any information about the effects of blood loss on the levels of blood sex hormones by ourselves. However, recently (1994) Hermans et al. exposed intermittent hypoxia to rats during gestation. They demonstrated that prenatally hypoxic male rats exhibited significantly decreased blood testosterone levels in adulthood. Our finding shows that serious acute blood loss affects the levels of plasma testosterone, FSH, and LH in adult male rats. It is known that serious blood loss can cause hypoxia in tissues. Therefore, it was cosidered that the changes in the levels of plasma sex hormone related with blood loss might be due to the influence of hypoxia.
Keywords: Blood loss, Hypoxia, Testosterone,Follicle stimulating hormone, Luteinizing hormone, Radioimmunoassay,
Male rats
Turkiye Klinikleri J Med Sci 1996, 16:440-442
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