ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Intestinal Ischemia And Free Radical Metabolism
Muammer KARAAYVAZ*, H.Serdar ÖZTÜRK**, Serenay ELGÜN**,
Murat KAÇMAZ**, Orhan CANBOLAT***, Hikmet AKGÜL****
*Dr.Ankara Üniversitesi Tıp Fakültesi Cerrahi Onkoloji BD,
**Dr.Ankara Üniversitesi Tıp Fakültesi Biyokimya ABD,
***Doç.Dr.Ankara Üniversitesi Tıp Fakültesi Biyokimya ABD,
****Prof.Dr.Ankara Üniversitesi Tıp Fakültesi Cerrahi Onkoloji BD, ANKARA
In this study, antioxidant defense system was investigated in the intestinal tissue samples after mesenteric ischemia and establishment of protective roles of allopurinol plus antioxidant vitamins combination was attempted. In the ischemic intestinal tissues, it has been established that CAT and SOD activities increased but GSH-Px activity unchanged relative to control tissue values. It has also been found that MDA levels significantly increased in the intestinal tissues after ischemia. This increase in the MDA levels was eliminated by antioxidant treatment. This shows the importance of antioxidant treatment in the prevention of ischemic injury.
Keywords: Intestinal ischemia, Free radicals
Turkiye Klinikleri J Med Sci 1996, 16:437-439
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