ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Alpha-2 Adrenergic Agonists In Pain Management
Ayşe (İncesu) GÜREL*, Özenç TİMLİOĞLU**
*Dr.Gazi Üniversitesi Sağlık Bilimleri Enstitüsü Farmakoloji ABD,
**Prof.Dr.Gazi Üniversitesi Tıp Fakültesi Farmakoloji ABD, ANKARA
Researchers have decided to find out new drugs in controlling pain because opioids develop tolerance and respiratory depression in spite of their strong analgesic activities. The analgesic effects of alpha-2 (a2) adrenergic agonists have been known for many years. These compounds’ potentiating effect of opioid induced analgesia have been shown. Clonidine, which has been available for clinical use for many years, is the most extensively studied drug in this field. It is an a2 adrenergic receptor agonist of the imidazol class with some a1 agonistic pro-perties. Medetomidine and its D-enantiomer dexmedetomidine are more selective a2 agonists. They are introduced for clinical use. Other selective agonists ST91 and azepexole are now being used in animal studies. a2 agonists lower blood pressure, decrease heart rate and improve haemodynamic stability during anaesthesia and surgery. They prevent and stop post-anaesthetic tremor and lengthen the duration of local anaesthetic blockade.
Keywords: Analgesia, a2 adrenoreceptor agonist, Clonidine, Medetomidine, Dexmedetomidine
Turkiye Klinikleri J Med Sci 1996, 16:360-363
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