ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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The Short-term Effects Of Different Bronchodilatatorsin Patients With Stable Chronic Obstructive Pulmonary Disease
Günnur ÖZBAKIŞ*, A.Metin GÖRGÜNER**, İlknur GÖRGÜNER***, Z.Nur BANOĞLU****
*Dr.Erzurum Göğüs Hastalıkları ve Göğüs Cerrahi Merkezi,
**Yrd.Doç.Dr.AÜ Tıp Fakültesi Göğüs Hastalıkları ABD,
***Uz.Dr.Erzurum Göğüs Hastalıkları ve Göğüs Cerrahi Merkezi,
****Prof.Dr.AÜ Tıp Fakültesi Farmakoloji ABD, ERZURUM
In this study, we investigated that the short-term effects of salbutamol which is a symphathomimetic agent, ipratropium bromide which is an anticholinergic agent and combination of these drugs as placebo controlled in 45 patients with stable chronic obstructive pulmonary disease. The baseline parameters were meassured for each patient, then drugs were administrated by inhalation and sistolic-diastolic blood pressure, pulse rate and spirometric parameters were determined at 10., 30., and 120. minutes. We observed that especially combinde therapy resulted in statistically significant increases in blood pressure at each time internval. Salbutamol caused statistically significant increase in pulse rate at 30. min, combined therapy also caused an increase at 10., 30. and 120. minutes. On the other hand, while combined therapy and salbutamol caused prominent increases in pulmonary function parameters at each time interval, ipratropium increased only 30. and 120. minutes. In conclusion, we thought that both salbutamol and ipratropium bromide can be reliably used by inhalation in treatment of stable chronic obstructive pulmonary disease, and salbutamol must be preferred in acute cases since its broncholidator effect starts earlier. In addition, combined therapy is more effective on respiratory functions than one drug usage.
Keywords: Salbutamol, Ipratropium bromide,
Pulmonary function test, COPD
Turkiye Klinikleri J Med Sci 1996, 16:381-386
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