ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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The Role Of Nitric Oxide In Non-adrenergicnon-cholinergic Neurotransmission In Gastrointestinal System
İrfan KAPUTLU*
*Dr.Akdeniz Üniversitesi Tıp Fakültesi Farmakoloji ABD, ANTALYA
The motility of the mammalian intestine is regulated by a complex network of neurones and nerve fibres of both intrinsic and extrinsic origin. Physiological experiments have established that in addition to cholinergic and adrenergic nerves, non-adrenergic non-cholinergic (NANC) nerves also exist in the gut which are thought to take part in descending relaxation. Stimulation of these nerves, either by field stimulation or via neural reflex pathyways, elicits hyperpolarization of postjunctional smooth muscle membranes referred to as inhibitory junction potentials and relaxation. However, the exact nature of the inhibitory neurotransmitter released by inhibitory NANC neurones still remains controversial, Mainly, vasoactive intestinal polypeptide (VIP) or adenosine 5’-triphosphate (ATP) have been suggested as the putative NANC neurotransmitter. Recently, many evidence provided in support of the proposal that nitric oxide is the inhibitory NANC neurotransmitter in various tissues. Further studies on nitrergic transmission will provide new insights into physiological control mechanisms and pathophysiological control mechanisms and pathophysiological processes and may lead to new therapeutic developments.
Keywords: Gastrointestinal motility, Non-adrenergic non-cholinergic neurotransmission,Nitrergic nerves, Nitric oxide
Turkiye Klinikleri J Med Sci 1996, 16:338-342
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