ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Clinical And Toxicological Importance Of Glutathione S-transferases
Uz.Ecz.Hilmi ORHAN*, Doç.Dr.Gönül ŞAHİN*
*Hacettepe Üniversitesi Eczacılık Fakültesi Farmasötik Toksikoloji AD, ANKARA
Glutathione S-transferases (GST) are a complex group of detoxification enzymes that catalyse the conjugation of glutathione (GSH) with a broad spectrum of electrophiles. They can be found in the cytosol or in microsomes. Human cystosolic GST?s are divided in class a, m, p Ø. The functions of GST?s may be classified into two general categories. THe main and most important function of the enzymes is believed to be detoxification of reactive intermediates in the metabolism of xenobiotics. Interest has also focused on the ağabeylity of these proteins to protect against harmful products formed during oxidative stres, such as hydroperoxides from lipids and DNA, as well as 4-hydroxyalk-2-enals. Secondly, they bind a number of amphipathic compounds that they do not metabolize (nonsubstrate ligands) and have been suggested to act as intracellular transport proteins for compounds that have limited solubility in water.
GSTS?s have been found at high levels in mammalian tumor cells. As a result it is one of the mechanisms responsible for multidrug resistance (MDR). THese enzymes recently have been suggested as a biomarker for detection of different types of neoplasia liver and kidney damage and exposure to some industrial and environmental chemicals. ALl these areas are currently and extensively investigated.
Keywords: Glutathione S-transferase, Detoxication, Biomarker, Electrophilic xenobiotic
Turkiye Klinikleri J Med Sci 1995, 15:303-315
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