ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Lisuiride Combined With Levodopa In The Treatment Of Advanced Parkinson?s Disease
Dr.M. Murat SÜMER*, Dr.Neşe ÖZTEKİN*, Dr.Şenay ÖZBAKIR*
*SSK Ankara Hospital Neurology Department, ANKARA
22 patients with advanced Parkinson?s disease were studied, all having a deteriorating response to levodopa and suffering from daily fluctuations in disability. An open study was performed. Lisuride was added 0.1 mg daily and increased in four weeks period. After reaching the optimal dose, it is given at fixed dose in two/three weeks period. Optimal daily lisuride dose was 1.2 mg (range 0.8-1.2 mg). Mean levodopa dose was reduced from 650 mg to 520 mg.
16 patients completed the 6-8 weeks trial. THe addition of lisuride resulted significant improvement of parkinsonian disability. AMong the patients with ?on-off? phenomena, there was an increase in ?on? period from 8 hours to 11 hours and end of dose deterioration was delayed from 2 hours to 3 hours. All of these changes were significant (p<0.01). It seems that lisuride was effective on parkinosian disability and fluctuations in advanced Parkinson?s disease.
Keywords: Lisuride, Advanced Parkinson?s disease
Turkiye Klinikleri J Med Sci 1996, 16:86-89
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