ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Etiopathogenesis Of Nocturnal Worsening In Asthma
*Karadeniz Teknik Üniversitesi Tıp Fakültesi İç Hastalıkları AD, Göğüs Hastalıkları AD Öğretim Üyesi, TRABZON
**Ege Üniversitesi Tıp Fakültesi Göğüs Hastalıkları AD, İZMİR
Over 80% of people with asthma experience nocturnal attack characterised by cough, wheeze and breathlessness at night. There is a normal circadian variation in pulmonary functions. Asthmatic patients show much greater amplitude in thus rithm. The underlying mechanisms are not yet fully clear but several causative factors for this increased responsiveness at night have been mentioned. Some physiologic variables including sleep, supine posture, airway cooling, changes in epinephrine, cortisol and histamine levels, inhibition of NANC system and coincidental pathogies as well as GOR, sinusitis and sleep apnea are sugested as responsible factors. It has been believed that the common mechanism for these factors is bronchial hyperresponsiveness due to airway inflammation.
Keywords: Asthma, Circadian rithm, Nocturnal worsening
Turkiye Klinikleri J Med Sci 1996, 16:27-33
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