ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Novel Interleukins
Nurdan LENK*, Arzu KÜRKLÜ**, M. Yavuz KÖKER***, Nuran ALLI*
*Dermatologist, Department of Dermatology, Numune Hospital
**Biologist, Research Institute, Hacettepe University
***Medical Doctor, Emergency Service, Ankara Hospital, ANKARA
The effector phases of both natural and specific immunity are in large part mediated by protein hormones called cytokines. Early studies of cytokines, extending from about 1950 to 1970, largely involved the description of numerous protein factors produced by different cells that mediated particular functions in particular bioassays. An important hypothesis generated at this time was that cytokines were principally synthesized by leukocytes and primarily acted on (other) leukocytes, and thus could be called as interleukins. The golden age of cytokine research began in the 1980s. It has been characterized by the molecular cloning and expression of individual cytokine molecules and by the production of completely specific, often monoclonal, neutralizing antibodies (1). In subsequent years, many new cytokines were discovered and many previously unexpected properties of known cytokines were revealed and occured everexpanding cytokine network.
Turkiye Klinikleri J Med Sci 1996, 16: 299-303
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