ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
|
|
|
|
Superoxide Dismatuse And Glutathione Peroxidase In Behçet?s Disease
Dr.Yavuz BAYKAL*, Dr.Ahmet TÜZÜN*, Dr.Şeref KÖMÜRCÜ**, Dr.Bayram KOÇ*, Dr.Refik MAS*, Dr.Çağlayan ÖZDEMİR*, Dr.Tahir ÜNAL*, Dr.Fikri KOCABALKAN*
*Gülhane Military Medical Academy Internal Medicine Department
**Gülhane Military Medical Academy Medical Oncology Department, ANKARA
It has recently been suggested that excessively generated free oxygen radicals also play a role in the pathogenesis of various diseases. In this study, Superoxide Dismutase (SOD) and Glutathione Peroxidase (GSH-Px) activities were measured in erythrocytes in order to find out the role of oxidative stres in the etiopathogenesis of Behçet?s Disease.
The study was performed on 33 patients with Behçet?s Disease and age and sex-matched 37 healthy control subjects. It was found that the SOD activities in patients with Behçet?s Disease were significantly lower than those of controls (178.65±45.73 mg/ml vs. 200.92±44.68 mg/ml, (p<0.05). Although the GSH-Px activities in those patients were lower than those of the control subjects, this difference wasn?t statistically significant (2.9427±0.892 U/ml. Vs. 3.1051±0.713 U/ml., p>0.05). When SOD and GSH-Px values were compared in active and inactive patients with Behçet?s Disease, no significant difference was noted.
Consequently, excessive amount of free oxygen radicals may be responsible for the etiopathogenesis of Behçet?s Disease or at least they may contribute to it. THis is possibly due to diminished SOD activity but further studies are required to find out the exact role of SOD and GSH-Px activities in the etiopathogenesis of Behçet?s disease.
Keywords: Behçet hastalığı, Süperoksit dismutaz, Glutatyon peroksidaz
Turkiye Klinikleri J Med Sci 1996, 16:277-280
|
|
|
|
|
