ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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The Long-term Effects Of Different Bronchodilatators In Patients With Stable Chronic Obstructive Pulmonary Disease
Dr.Günnur ÖZBAKIŞ*, Yrd.Doç.Dr.A. Metin GÖRGÜNER**, Uz.Dr.İlknur GÖRGÜNER*, Prof.Dr.Z. Nur BANOĞLU***
*Erzurum Göğüs Hastalıkları ve Göğüs Cerrahisi Merkezi
**Atatürk Üniversitesi Tıp Fakültesi Göğüs Hastalıkları AD
***Atatürk Üniversitesi Tıp Fakültesi Farmakoloji AD, ERZURUM
In this study, we investigated that the long-term effects of salbutamol which is a sympathomimetic agent, ipratropium bromide which is an anticholinergic agent and combination of these drugs, and whether theophylline addition contributes to outcome in patients with stable chronic obstructive pulmonary disease. The study was planned with salbutamol inhalation to 15 patients, ipratropium bromide inhalation to 15 patients and salbutamol+ipratropium bromide inhalation to 15 patients during two weeks. At the beginning of second week, a long-acting theophylline preparation was orally added to the treatment. In the course of study, the daily symptoms scores and side effects were noticed. The pulmonary function test of patients who had completed the study, were separately repeated at the end of the first and second weeks, and the same spirometric parameters were obtained. All of the rises were found statistically significant except that increase of FVC at the end of the first week, and increases of FEV1 at the end of both the first and second weeks in the group who administrated ipratropium bromide alone. It was especially more significant in the combined therapy. There was not statistically significant difference among the groups for cough, dyspnea and sputum production symptoms. In conclusion, we thought that both salbutamol and ipratropium bromide can be reliably used by inhalation in treatment of stable chronic obstructive pulmonary disease. In addition, the combined therapy is more effective on respiratory function than one drug usage. Finally, although the addition of oral theophylline contributes to increase of bronchodilatation, it appeared not to play a part on the relief of patient?s symptoms.
Keywords: Salbutamol, Ipratropium bromide, Theophylline, Pulmonary function test, COPD
Turkiye Klinikleri J Med Sci 1996, 16:251-257
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