ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Histopathological And Prognostic Features Of Endometrial Carcinomas: A Retrospective Study
Dr.Sevgiye KAÇAR ÖZKARA,a Dr. Aydın ÇORAKÇI,b Dr. Nilay ETİLER,c
Patoloji ADa, Kadın Hastalıkları ve Doğum ADb, Halk Sağlığı ADc, Kocaeli Üniversitesi Tıp Fakültesi, KOCAELİ
Objective: The aim of this retrospective study was to provide a statistical evaluation of clinico-pathologic parameters (i.e. age, menopausal status, tumor size, histopathologic subtype, grade, lymph node involvement, peritoneal cytology, stage and endometrial hyperplasia) of endometrial carcinoma presentations with a survey of attendant clinical follow-up.
Material and Methods: The study group was composed of 41 cases of endometrial carcinoma which were diagnosed, treated and followed in Kocaeli University Medical Faculty Hospital between 1996-2003. Hematoxylin and eosin stained sections of specimens from these cases were re-evaluated using World Health Organisation classification and International Federation of Gynecology and Obstetrics 1988 staging schemes. The histopathological and clinical follow-up findings were then analyzed statistically.
Results: The mean age of the patients was 58.8 years. The most common histopathologic tumor type was endometrioid adenocarcinoma (39/41). The majority of the tumors were low grade (20/41), while 6 cases were graded as high. Myometrial invasion was present in 27 cases, while 14 cases were limited to the endometrium. Thirty-three cases were stage I and no case was present at stage IV. Two of the 34 cases with lymph node dissection had metastases. Hyperplasia was observed in the tumor-free endometrium in 17 cases. The cases were followed-up for a mean 38.8 months and 6 of them had a clinical progression. The statistical evaluation revealed significant association between the histopathologic tumor type and grade as well as lymph node metastasis. The clinical prognosis was significantly associated with the grade, depth of myometrial invasion, peritoneal cytology, stage and concurrent endometrial hyperplasia. Peritoneal cytology results were also significantly associated with the tumor size, grade, myometrial invasion, lymph node metastasis and stage (p<0.05). All of the cases with large tumor size, high grade, deep myometrial invasion, lymph node metastasis, positive peritoneal cytology, late stage or clinical progression involved patients over 45 years of age. Tumor size, histopathologic tumor type, depth of myometrial invasion, lymph node involvement, peritoneal cytology and stage had a significant effect on survival (p<0.05).
Conclusion: The histopathological and clinical evaluation of individual cases of endometrial carcinoma must be standardized in order to plan treatment modalities that are in accord with prognostic expectations.Keywords: Endometrium, carcinoma, prognosis, survivalTurkiye Klinikleri J Med Sci 2004, 24:247-260
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