ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Maturıty-onset Diabetes Of The Young
Dr.M. Emre ATABEK,a Dr.Selim KURTOĞLUa
aÇocuk Sağlığı ve Hastalıkları AD, Çocuk Endokrinolojisi ve Metabolizma Hastalıkları BD, Erciyes Üniversitesi Tıp Fakültesi, KAYSERİ
Maturity-onset diabetes of the young, (MODY) is a clinically heterogeneous group of disorders characterized by nonketotic diabetes mellitus, an autosomal dominant mode of inheritance, an onset usually before the age of 25 and frequently in childhood or adolescence, and a primary defect in the function of the beta cells of the pancreas. Separating typical type 2 diabetes mellitus (T2DM) into phenotypic subgroups has proved difficult. Single gene defects account for only around 5% of T2DM in most populations. The most common single gene disorder is MODY, which was originally described as familial, young onset non-insulin dependent diabetes. However, the term is now used to describe monogenic forms of diabetes of β-cell origin. Considerable progress has been made over the last 10 years in defining the genes and phenotypes involved. In contrast to T2DM genes, MODY genes were relatively simple to identify because of the young age of onset, which enabled the collection and close study of multigenerational families. In this study, a review of MODY is presented.Keywords: MODY, type 2 diabetesTurkiye Klinikleri J Med Sci 2004, 24:167-172
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