ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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A Multifunctional Peptide; Adrenomedullin
Dr.Özlem GÜNEYSELa
aAcil Tıp AD, Marmara Üniversitesi Tıp Fakültesi, İSTANBUL
Adrenomedullin (ADM) is a 52–amino acid endogenous vasodilator peptide discovered in 1993 by Drs. ETO and Kitamura in Japan. It was originally isolated from the extracts of human pheochromotomas. It has been reported that ADM mRNA is expressed in a variety of tissues / cells, including cultured vascular smooth muscle cells, cultured endothelial cells, heart, lung, kidneys, liver and intestines. ADM increases intracellular cAMP in vascular smooth muscle cells via its specific receptors. Other cell signaling mechanisms, such as a decline in intracellular calcium concentration, decreased calcium sensitivity of the contractile apparatus, and stimulation of nitric oxide formation are utilized to mediate the peptide’s biological actions in the body. ADM is produced and secreted from peripheral blood granulocytes, lymphocytes, monocytes, macrophages and fibroblasts, all of which are known to be involved in inflammatory process by the stimulation of the tumor necrosis factor, interleukin-1 and lipopolisacharide.
Plasma ADM levels are known to be increased in several clinical situations such as essential hypertension, congestive heart failure, acute myocardial infarction, chronic renal failure, and sepsis. ADM is considered to play an important role through its vasodilatory and natriuretic properties in maintaining physiological cardiovascular and renal homeostasis.Keywords: Adrenomedullin, vasodilator peptideTurkiye Klinikleri J Med Sci 2004, 24:159-166
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