ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Erythrocyte Arginase Levels In Down Syndrome And In Healthy Children
Serap ŞENEL, MD,a Cemil ÇELİK, MD,a Yüksel ALİYAZICIOĞLU, MD,a Haydar Ali TAŞDEMİR, MDb
aDepartment of Biochemistry, bDepartment of Pediatrics, Ondokuz Mayıs University School of Medicine, SAMSUN
Objective: Several different tissues in which the urea cycle does not take place harbor arginase activity. It has been reported that both liver and erythrocyte arginase levels were low in cases with mental retardation, cerebral palsy and hyperargininemia. The purpose of this study was to determine the erythrocyte arginase levels in cases with Down Syndrome (DS) and in healty children.
Material and Methods: Enzyme levels were measured in 20 children with DS (6.32 ± 1.40 years) and in 20 age-matched healthy children (5.8 ± 1.06 years). Erythrocyte arginase activity was measured by the modified Shimke method.
Results: No significant differences were detected between erythrocyte enzyme levels of the children with DS (22.86+0.67 U/g.Hb/min) and those of healthy children (21.89+1.03 U/g. Hb/min).
Conclusion: It was concluded that the level of erythrocyte arginase enzyme could not be considered as a useful marker for assessing the level of mental retardation children in DS.Keywords: Down syndrome, mental retardation, erythrocyte arginaseTurkiye Klinikleri J Med Sci 2004, 24:138-141
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