ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Evaluation Of Plasma Anticoagulant Protein Levels And Thrombin Time In Coal Miners
Dr.Ahmet GÜREL,a Dr.Ferah ARMUTCU,a Dr.Murat ÜNALACAK,b
Dr.Ali ÖZEREN,c Dr.Mustafa AYDIN,c Dr.Nejat DEMİRCANb
aBiyokimya AD, bAile Hekimliği AD, cKardiyoloji AD, Karaelmas Üniversitesi Tıp Fakültesi, ZONGULDAK
Objective: This study was planned to investigate alterations in the anticoagulant proteins; protein C, protein S and antithrombin III levels, as well as in thrombin time in coal miners exposed to coal dust. Coal dust increases fibroblast proliferation, extracellular matrix synthesis and secretion of proinflammatory factors. As such, the effect of coal dust is not restricted to the lungs, and various other organs may also be compromised. In particular, the increase in IL-6 and TNF-a levels seen in patients from this milieu leads to the assumption that coal dust may cause inflammation and other alterations that may have a direct hemodynamic effect upon the circulation.
Material and Methods: In this study, 34 males employed in coal mining were taken as a study cohort. 32 non-coal mining males functioned as a control group. Protein C, protein S and antithrombin III levels, as well as thrombin time were measured in blood samples from both groups.
Results: Protein C, protein S and antithrombin III levels were found to be significantly lower and thrombin time was found to be significantly higher in the study group when compared to those of the control group (p<0.001).
Conclusion: Due to low levels of anticoagulant proteins, coal miners manifest and increased risk of hypercoagulopathy and other related thromboembolic complications.Keywords: Coal miner, protein C, protein S, antithrombin III, thrombin timeTurkiye Klinikleri J Med Sci 2004, 24:125-129
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