ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
The Evaluation Of Bone Marrow Involvement In Haematologic Neoplasms With Magnetic Resonance Imaging
Dr.Bahriye PAYZİN,a Dr.Yeşim ADAKAN,b Dr.Mevlüt YİĞİTc, Dr.Selda ÇENELİ,b Dr.Murat ÇAKIR,d Dr.Yeşim ÜNLÜ,b Dr.Mehmet SONBAHARb, Dr.Mücahit ATALAYe
aHematoloji Kliniği, b2. İç Hastalıkları Kliniği, cRadyoloji Kliniği,d1. İç Hastalıkları Kliniği, eNükleer Tıp Kliniği,
Atatürk Eğitim ve Araştırma Hastanesi, İZMİR
Objective: In this study, the value of magnetic resonance imaging (MRI) as a non-invasive radioligical examination in the detection of bone marrow involvement in primary and secondary haemotologic neoplasms was discussed with comparison of concomitant MRI, computerized tomography (CT), sintigraphic evaluation (SE) and conventional bone graphies (CBG) with bone marrow biopsy (BMB) results.
Material and Methods: A group, totaling 29 patients, were admitted to our hospital between March 1999 and April 2000, consisting of 12 patients with Non-Hodgkin’s lymphoma, 6 patients with multiple myeloma, 5 patients with Hodgkin’s lymphoma, 2 patients with chronic lymphocytic leukemia, 2 patients with acute myeloid leukemia. 18 of them were male and eleven were female ( male/female:1,6), median age was 48 years (17-75). Bone marrow biopsy and radiological examinations were completed in 15 days during diagnosis and in 30 days after treatment. Sternal aspirations of patients with acute leukemia were repeated after chemotherapy when necessary. Sintigraphy of bone marrow using Tc99m nanocolloid was performed in all patients. In magnetic resonance imaging examination, Vectra devices capable of forming a 0,5 Tesla power constant magnetic field was used with selecting pelvis, lumbar vertebras and proximal femur where cellular marrow density was relatively higher, as examination sites. In all cases, the density was measured in T1 and T2-weighted images at involvement sites with ROI(region of interest) method.
Results: In our study; the sensitivites of radiologic examinations based on bone marrow biopsy in bone marrow involvement of haemotologic neoplasms were established as %100 in MRI, %90 in SE, %70 in CT and %61 in CBG.
Conclusion: We foresee that MRI will be used with increasing frequency as a non-invasive method in demonstrating the existence of primary or secondary bone marrow involvement in haemotologic neoplasms in surveillance and as a supportive adjunct to bone marrow biopsy in determining the actual stage in lymphomas.Keywords: Haematologic neoplasms, magnetic resonance imaging, bone marrow sintigraphy, bone marrow biopsyTurkiye Klinikleri J Med Sci 2004, 24:113-123
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