ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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A Case With Tumor Lysis Syndrome With Severe Hyperphosphatemia And Hyperuricemia Due To Fludarabine
Dr.Ali BORAZAN,a Dr.Yücel ÜSTÜNDAĞ,a Dr.Nedred SEKİTMEZ,a
Dr.Gülay KADIOĞLU,a Dr.Ahmet YILMAZb
aİç Hastalıkları AD, Zonguldak Karaelmas Üniversitesi Tıp Fakültesi, ZONGULDAK
bİç Hastalıkları AD, Kocaeli Üniversitesi Tıp Fakültesi, KOCAELİ
Tumor lysis syndrome (TLS) due to the use of fludarabine, a well known adenosine deaminase inhibitor, has been reported very rarely in patients with chronic lymphocytic leukemia (CLL). Generally; TLS happens to occur after the first course of chemotherapeutics.
In the present report, we describe a 70 year-old patient with a diagnosis of CLL nearly 7 years ago, who developed a severe acute renal failure after the third course of fludarabine treatment, resulting in TLS with a dramatic rise in serum phosphorus (32 mg/dl) and uric acid levels (46 mg/dl). Intensive hemodialysis treatment a meliorated the clinical course of renal failure within 7 days.
This case reminds us that TLS develop even after the third course of chemotherapautics in patients with CLL.Keywords: Chronic lymphocytic leukemia, fludarabine,tumor lysis syndromeTurkiye Klinikleri J Med Sci 2004, 24:98-100
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