ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Usefulness Of C-reactive Protein In Ardiovascular Disease As A Risk Factor
Dr.Emel ALTEKİN,a Dr.Banu ÖNVURALa
aBiyokimya AD, Dokuz Eylül Üniversitesi Tıp Fakültesi, İZMİR
Inflammation plays an important role in the initiation and progression of atherosclerosis and in the pathogenesis of acute cardiovascular events. C-reactive protein (CRP) is one of the major acute phase protein in humans. In subjects with normal liver function, plasma concentrations of CRP are a highly sensitive measure of overall inflammatory activity in the body. Recent studies have indicated a possible association between CRP and coronary artery disease (CAD). Prospective studies have consistently shown that CRP is strong predictor of future coronary events in apparently healthy men and women. The relative risk associated with CRP is suggested to be independent of other cardiovascular disease risks. The results of recent data suggest that the C-reactive protein level is a stronger predictor of cardiovascular events than LDL cholesterol levels and that, in addition, screening for both biologic markers provided better prognostic information than screening for either alone. In patients with established coronary disease, CRP has been shown to predict adverse clinical events. Elevated CRP levels have been shown in patients with angina pectoris to be associated with an increased risk of myocardial infarction and sudden death. High-sensitivity CRP (hs-CRP) assays are needed for risk assessment of cardiovascular disease. Such assays are currently available. Potential preventative therapeutic approaches to decrease coronary risk in those with increased hs-CRP concentrations are currently under investigation. In this review article, we aim to examine the association between CRP and CAD in the light of the current literature.Keywords: C-rective protein, atherosclerosis,coronary artery diseaseTurkiye Klinikleri J Med Sci 2004, 24:57-61
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