ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Effects Of Propofol And Tramadol On Cholinergic Receptor-mediated Responses Of The Isolated Rat Ileum
Tijen KAYA, MD,a Gökhan KÖYLÜOĞLU, MD,b Sinan GÜRSOY, MD,c Nur KUNT, MD,c Haluk KAFALI, MD,c Ahmet Serdar SOYDAN, MDa
aDepartment of Pharmacology, bDepartment of Pediatric Surgery, cDepartment of Anaesthesiology, Cumhuriyet University School of Medicine, SİVAS
Objective: The present study was designed to evaluate the direct effects on basal tension and its effects on the cholinergic receptor-mediated responses of propofol and tramadol in the isolated rat ileum.
Material and Methods: Full thickness segments of ileum were obtained from rats (n=8) and placed in longitudinal direction in a 10 ml organ bath. The direct effects of propofol (10-8-10-5 M) and tramadol (10-6-10-3 M) at basal tension and the concentration-response curves for carbachol (10-9-10-4 M) in the presence and absence of propofol (10-7-10-6 M) and tramadol (10-5-10-4 M) were recorded isometrically with a Grass model 79 E polygraph.
Results: Propofol significantly reduced basal tension of ileal smooth muscle at 10-5 M concentration. Tramadol slightly reduced basal tension only at 10-3 M concentration. The contractile response of the ileum to exogenously applied carbachol was not influenced by propofol at concentration of 10-7 M, but was inhibited at 10-6 M concentration. In the presence of 10-6 M propofol, the concentration-response curve for carbachol was shifted to the right with significantly lower Emax and pD2 values when compared to control values. Carbachol-induced concentration-response curve did not significantly change in the presence of 10-5 and 10-4 M tramadol.
Conclusion: Results obtained suggest that propofol reduces basal tension and cholinergic response on the rat ileum in vitro, but tramadol does not.Keywords: Anesthetics, propofol, tramadol, ileum, ratTurkiye Klinikleri J Med Sci 2004, 24:52-56
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