ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Mechanism Of Seratonin-induced Gastric Mucosal Injury In Rats: Role Of Acid-back Diffusion
Mukaddes GÜMÜŞTEKİN, MD,ac Sedef GİDENER, MD,ac Meral KOYUNCUOĞLU, MD,bc
Fatma ERBOY,c Gönül YILDIZ,c
aDepartment of Pharmacology, bDepartment of Pathology, cDokuz Eylül University School of Medicine, İZMİR
Objective: It is known that, in rats, seratonin (5-HT) causes acute gastric mucosal injury due to decreased gastric mucosal blood flow (GMBF) resulting from vasoconstriction. Decreased gastric acid secretion in 5-HT-induced gastric injury has been described. The purpose of this study was to investigate whether the increase in acid back diffusion had an effect on 5-HT-induced gastric mucosal injury, in addition to the known effect on GMBF.
Material and Methods: Acute gastric mucosal injury was induced by the intra-peritoneal administration of 5-HT in 29 Wistar male rats. The animals were divided into four groups, the first control (5-HT only, n=7), the three others who were treated with either 10% polyethylene glycol, 2 µmol/kg omeprazole (n=8) or 10µmol/kg omeprazole (n=8) injected into the femoral vein one hour before 5-HT administration. The stomachs were subsequently removed and the severity of ulcers, if present was assessed using a previously validated scale, the histological ulcer index (HUI).
Results: In the group receiving 10µmol/kg of omeprazole, the HUI was significantly (p= 0.001) less than that seen with 5-HT alone. However, low dose omeprazole and PEG reduced HUI to a similar degree.
Conclusion: These results suggest that high doses of omeprazole decrease 5-HT-induced gastric injury and this might be related to the inhibition of the proton pump by omeprazole, which decreases H+ output and thus, indirectly prevents acid back diffusion.Keywords: Rat, serotonin, omeprazole, mucosal injury,acid-back diffusionTurkiye Klinikleri J Med Sci 2004, 24:47-51
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